New research indicates that people who come off new slimming jabs like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who halt conventional lifestyle programs.
Published data in a major health publication demonstrates that while overweight individuals often shed about a fifth of their body weight while using the jabs, the mass comes back at an average rate of nearly a kilo each month once they quit.
"People buying such drugs need to be cognizant of the potential of quick weight regain when the medication concludes," warns researcher Dr. Susan Jebb.
This pace of recovery means a reversion to starting weight within about 18 months.
Comparing Therapies
The research, which reviewed dozens of studies involving over 9,000 of participants, compared the results of GLP-1 agonists with older methods.
Researchers point out that individuals who lose weight through dieting usually see a more gradual weight regain—approximately 100 grams monthly—once they finish.
Explaining the Quick Rebound
Experts suggest the way of the drugs accounts for the amplified weight return.
GLP-1 drugs copy a natural hormone called glucagon-like peptide-1, which controls hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and may also diminish sensitivity to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication means hunger is unsuppressed, making binge eating much more probable."
An Ongoing Condition?
The NHS suggest the jabs for individuals with obesity-related health risks, alongside recommended lifestyle changes.
A number of clinicians contend that, considering the high risk of relapse, the therapy should be considered long-term.
This perspective is reinforced by pharmaceutical companies, who note that the findings "underscore the chronic nature of excess weight," comparing it to managing diseases like hypertension.
Patient Testimonies
Users who have discontinued the medication describe a powerful resurgence of appetite.
"It was like something that goes on and you're instantly extremely hungry," said an individual.
This challenge is compounded if individuals have not developed lasting dietary or behavioural modifications during therapy.
Widespread Interest
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with interest continuing to grow.
- Use is higher among females compared to men.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Finally, experts caution that while these medications are effective tools for weight loss, they are not a permanent fix and long-term success likely depends on combined behavioural support.
